RIPA, an innovation platform in imaging and radiochemistry serving health research.
Since 2013, GIP CYROI has operated a laboratory dedicated to research and development in radiochemistry and preclinical imaging: RIPA (Radiochimie et Imagerie du Petit Animal – Radiochemistry and Small Animal Imaging). The team offers its expertise to academic laboratories and biotechnology companies for their R&D projects.
It notably develops innovative and experimental radiotracers for preclinical studies. The design of new labelled molecules requires sophisticated radiosynthesis protocols, integrating starting ligands specifically designed to facilitate radionuclide incorporation. The team is able to cover the entire value chain, from the chemical synthesis of the ligand to the preclinical study, thanks to its state-of-the-art equipment.
OUR AREAS OF EXPERTISE
Study design, from chemical synthesis to in vivo experimentation
Custom organic synthesis and chemical analyses
Available equipment: Dedicated organic synthesis laboratory, ¹H/¹³C NMR (600 MHz); 1 HPLC HR-MS; 1 UHPLC
Radiochemistry
Available equipment: 2 laboratories with hot cells, 2 GE TracerLab FX FN synthesis modules, 2 UHPLC, Perkin Elmer Wizard 2480 gamma counter – Cyclone Plus Phosphor-Imager autoradiography
Services: Production of radioisotopes (¹⁸F, ⁶⁸Ga, ⁹⁹ᵐTc, ⁸⁹Zr, ¹⁷⁷Lu) and radiolabelling, purifications, quality control, stability studies, formulation for in vivo injection
Preclinical imaging
Available equipment: 1 dedicated laboratory, 1 LABPET 8 Triumph II Trifoil Imaging multimodal micro-PET/SPECT/CT imager, 1 VECTor7 MILABS micro-PET/SPECT/CT/OI imager (available end of 2025)
Services : Design of preclinical imaging protocols, preparation of ethics applications for animal research authorisation, animal model setup, radiotracer injections, image acquisition, reconstruction and analysis, biodistribution studies
OUR RESEARCH PROJECTS
FLUOTENSINE PROJECT
Selective radiofluorination of neurotensin analogues for improved pre-therapeutic PET imaging.
In collaboration with:
- INCIA, UMR CNRS 5287, University of Bordeaux
- IBMM, UMR 5247, University of Montpellier
Funded by:
Related publications:
RUNTHERANOS PROJECT
New radiotheranostic tools – tumour targeting by radiolabelled peptides specific to Neuropeptide Y receptors.
In collaboration with:
- INCIA, UMR CNRS 5287, University of Bordeaux
- Institut für Biochemie und Bioorganische Chemie, University of Leipzig (Germany)
Funded by:
